Systemic Lupus Erythematosus and implications for the oral cavity
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Submitted
September 16, 2020
September 16, 2020
Published
September 22, 2020
September 22, 2020
Abstract
Systemic Lupus Erythematosus affects several people around the world and because it is characterized as a chronic inflammatory disease of multifactorial origin, and with systemic impairment, great attention must be paid from diagnosis to treatment in order to optimize the entire follow-up of the patient.
The dental doctor plays an important role in the diagnosis of the condition and must be attentive to the early signs that can appear in the oral cavity with a frequency of up to 21%.
In this way, through this bibliographic review, which has as main goal to correlate Systemic Lupus Erythematosus with its direct consequences in the oral cavity, it will be possible to help dentists in the diagnosis, to understand in detail the development of the disease and what attitude should be taken in its presence.
References
1. Fernandes E, Savioli C, Siqueira J, Silva C. Oral health and the masticatory system in juvenile systemic lupus erythematosus. Lupus. 2007; 16(9):713-9
2. Umbelino Júnior AA, Cantisano MH, Klumb EM, Dias EP, da Silva AA. Achados bucais e laboratoriais em pacientes com lúpus eritematoso sistêmico. J Bras Patol Med Lab. 2010; 46(6):479-86
3. Amaral COF, Dias AL, et al. Estudo das características estomatológicas e sistêmicas em pacientes com lúpus eritematosos sistêmico. Rev Assoc Paul Cir Dent. 2014; 68(3):223-34
4. Khatibi M, Shakoorpour AH, Jahromi ZM, Ahmadzadeh A. The prevalence of oral mucosal lesions and related factors in 188 patients with systemic lupus erythematosus. Lupus. 2012; 21(12):1312-5
5. Fabbri C, Fuller R, Bonfá E, Guedes LKN, D’Alleva PSR, Borba EF. Periodontitis treatment improves systemic lupus erythematosus response to immunosuppressive therapy. Clin Rheumatol. 2014; 33(4):505-9
6. Hochberg MC. Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheumatol. 1997; 40(9):1725
7. Menzies S, O’Shea F, Galvin S, Wynne B. Oral manifestations of lupus. Ir J Med Sci. 2017; 187(1):91-3
8. Albilia JB, Lam DK, Clokie CML, Sándor GKB. Systemic Lupus Erythematosus: a review for Dentists. J Can Dent Assoc. 2007; 73(9):823-8
9. Fernandes M, Taulaigo A, Vidal C, Agostini P, Riso N, Moraes-Fontes MF. Heterogeneous lupus-specific lesions and treatment outcome, in a single patient, over a period of time. Clin Case Rep. 2019; 7(5):865-71
10. Hammoudeh M, Al-Momani A, Sarakbi H, Chandra P, Hammoudeh S. Oral manifestations of Systemic Lupus Erythematosus patients in Qatar: A pilot study. Int J Rheumatol. 2018; 2018(12):1-6
11. De Rossi SS, Glick M. (1998). Lupus erythematosus: considerations for dentistry. J Am Dent Assoc. 1998; 129(3):330-9
12. Brennan MT, Valerin MA, Napeñas JJ, Lockhart PB. Oral manifestations of patients with lupus erythematosus. Dent Clin N Am. 2005; 49(1):127-41
13. Lanna CCD, Ferreira GA, Telles RW. Lúpus eritematoso sistêmico. Reumatologia: Diagnóstico e tratamento. 4th ed. São Paulo: Ed. A.C, Farmacêutica, 2014; 378-410
14. Hahn BH, Karpouzas GA, Gsao BP. Systemic lupus erythematosus and related syndromes – Pathogenesis of systemic lupus erythematosus. Kelley's Textbook of Rheumatology. USA: Elsevier Saunders ed. 2005; 1174-200
15. Rhodes B, Vyse TJ. The genetics of SLE: an update in the light of genome-wide association studies. Rheumatology. 2008; 47:1603-11
16. Muñoz LE, van Bavel C, Franz S, Berden J, Herrmann M, van der Vlag J. Apoptosis in the pathogenesis of systemic lupus erythematosus. Lupus. 2008; 17(5):371-5
17. Fu SM, Deshmukh US, Gaskin F. Pathogenesis of systemic lupus erythematosus revisited end organ resistance to damage, autoantibody initiation and diversification, and HLA-DR. J Autoimmun. 2011; 37(6):104-12
18. Akizuki S, Ishigaki K, et al. PLD4 is a genetic determinant to systemic lupus erythematosus and involved in murine autoimmune phenotypes. Ann Rheum Dis. 2019; 78(4):509-18
19. Louis PJ, Fernandes R. Review of systemic lupus erythematosus. Oral Surg Oral Med Oral Pathol Oral Radiol. 2001; 91(5):512-8
20. Bourré-Tessier J, Peschken CA, et al. Association of Smoking with cutaneous manifestations in Systemic Lupus Erythematosus. Arthritis Care Res. 2013; 65(8):1275-80
21. Kamen DL. Environmental influences on Systemic Lupus Erythematosus expression. Rheum Dis Clin North Am. 2014; 40(3):401-7
22. Mays JW, Sarmadi M, Moutsopoulos NM. Oral manifestations of systemic autoimmune and inflammatory diseases: diagnosis and clinical management. J Evid Based Dent Pract. 2012; 12(3):265-82
23. Calderaro DC, Ferreira GA, et al. Há associação entre o lúpus eritematoso sistêmico e a doença periodontal? Rev Bras Reumatol. 2016; 56(3):280-4
24. Mutlu S, Richards A, Maddison P, Scully C. Gingival and periodontal health in systemic lupus erythematosus. Community Dent Oral Epidemiol. 1993; 21(3):158-61
25. Kobayashi T, Ito S, et al. Risk of periodontitis in systemic Lupus Erythematosus is associated with Fcγ receptor polymorphisms. J Periodontol. 2003; 74(3):378-84
26. Trail AC, Claiborne DM. Treating patients with lupus. Dim Dent Hyg. 2013; 11(10):53-7
27. Gilboe IM, Kvien TK, Husby G. Disease course in systemic lupus erythematosus: changes in health status, disease activity, and organ damage after 2 years. J Rheumatol. 2001; 28:266-74
28. Grimaldo-Carjevschi M, Lòpez-Labady J, Villarroel-Dorrego M. Squamous cell carcinoma on the palate with systemic lupus erythematosus: case report and review of literature. Lupus. 2011; 20(5):519-22
29. Downey MC, Hughes CT, Winkley GP. Systemic lupus erythematosus: a review for dental professionals. J Dent Hyg. 1998; 72(2):35-40
30. Wallace DJ. Cutaneous and cutaneovascular manifestation of systemic lupus erythematosus. Dubois lupus erythematosus, 5th ed. 1997; 693-722
31. Duarte AA. Fator antinúcleo na dermatologia. Anais Bras Dermatol. 2005; 80(4):387-94
32. Vaz AJ, Takei K, Bueno EC. Imunoensaios Fundamentos e Aplicações. Guanabara Koogan. 2007
33. Sonis ST, Fazio RC, Fang L. Lesões brancas: lupo eritematoso. In: Medicina Oral. 4th ed. Rio de Janeiro, Guanabara Koogan, 1986.
34. Scully C. Medicina Oral e Maxilofacial: Bases do Diagnóstico e Tratamento. 2nd (Ed). London, Elsevier. 2008; 392
35. Chi AC, Neville BW, Krayer JW, Gonsalves WC. Oral manifestations of systemic disease. Am Family Physician. 2010; 82(11):1381-8
36. Nico MMS, Vilela MAC, Rivitti EA, Lourenço SV. Oral lesions in lupus erythematosus: correlation whit cutaneous lesions. Eur J Dermatol. 2008; 19(4):376-81
37. Callen JP. Oral manifestations of collagen vascular disease. Semin Cutan Med Surg. 1997; 116(4):323-7
38. Aliko A, Alushi A, Tafaj A, Lela F. Oral mucosa involvement in rheumatoid arthritis, systemic lupus erythematosus and systemic sclerosis. Int Dent J. 2010; 60(5):353-8
39. Shiodt M. Oral manifestations of lupus erythematosus. Int J Oral Surg. 1984; 13(2):101-47
40. Hughes CT, Downey MC, Winkley GP. Systemic lupus erythematosus: a review for dental professionals. J Dent Hyg. 1998; 72(2):35-40
41. Parslow RC, McKinney PA, Law GR, Bodansky HJ. Population mixing and childhood diabetes. Int J Epidemiol. 2001; 30(3):533-8.
42. Tsokos GC. Systemic lupus erythematosus. N Engl J Med. 2011; 365(22):2110-21
43. Mustafa MB, Porter SR, Smoller BR, Sitaru C. Oral mucosal manifestations of autoimmune skin diseases. Autoimmun Rev. 2015; 14(10):930-51
44. Orteu CH, Buchanan JA, Hutchison I, Leigh IM, Bull RH. Systemic lupus erythematosus presenting with oral mucosal lesions: easily missed? Braz J Dermatol. 2001; 144(6):1219-23
45. Delavarian Z, Chaghmaghi MA, Mozafari PM, Fard MRH, Saati S. Role of oral medicine specialist in disclosing systemic lupus erythematosus: A diagnostic dilema. Ind J Dental Edu. 2010; 3(3):121-6
46. Marques ERMC, Lourenço SV, Lima DM, Nico MMS. Oral lesions in lupus erythematosus-cytokines profiles of inflammatory infiltrate. J Cutan Pathol. 2010; 37(4):439-45
47. Lourenço SV, Carvalho FRG, et al. Lupus erythematosus: clinical and histopathological study of oral manifestations and immunohistochemical profile of the inflammatory infiltrate. J Cutan Pathol. 2007; 34(7):558-64
48. Sontheimer RD. Lupus erythematosus. Fitzapatrick’S Dermatology in General Medicine. 2003; 6(11):1677-93
49. Gonçalves LM, Bezerra Júnior JRS, da Cruz MCFN. Avaliação clínica das lesões orais associadas a doenças dermatológicas. Anais Bras Dermatol. 2010; 85(2):150-6
50. Wang Z, Wang Y, et al. Long-term survival and death causes of systemic lupus erythematosus in China: a systemic review of observational studies. Medicine. 2015; 94(17):e794
51. Kobayashi T, Ito S, et al. The combined genotypes of stimulatory and inhibitory Fcγ receptors associated with systemic lupus erythematosus and periodontitis in Japanese adults. J Periodontol. 2007; 78(3):467-74
52. Manoussakis MN, Georgopoulou C, et al. Sjorgren’s syndrome associated with systemic lupus erythematosus: clinical and laboratory profiles and comparison with primary Sjogren’s syndrome. Athritis Rheumatol. 2004; 50(3):882-91
53. Szanto A, Szodoray P, Kiss E, Kapitany A, Szegedi G, Zeher M. Clinical serologic, and genetic profiles of patients with associated Sjögrens syndrome and systemic lupus erythematosus. Human Immunol. 2006; 67(11):924-30
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2. Umbelino Júnior AA, Cantisano MH, Klumb EM, Dias EP, da Silva AA. Achados bucais e laboratoriais em pacientes com lúpus eritematoso sistêmico. J Bras Patol Med Lab. 2010; 46(6):479-86
3. Amaral COF, Dias AL, et al. Estudo das características estomatológicas e sistêmicas em pacientes com lúpus eritematosos sistêmico. Rev Assoc Paul Cir Dent. 2014; 68(3):223-34
4. Khatibi M, Shakoorpour AH, Jahromi ZM, Ahmadzadeh A. The prevalence of oral mucosal lesions and related factors in 188 patients with systemic lupus erythematosus. Lupus. 2012; 21(12):1312-5
5. Fabbri C, Fuller R, Bonfá E, Guedes LKN, D’Alleva PSR, Borba EF. Periodontitis treatment improves systemic lupus erythematosus response to immunosuppressive therapy. Clin Rheumatol. 2014; 33(4):505-9
6. Hochberg MC. Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheumatol. 1997; 40(9):1725
7. Menzies S, O’Shea F, Galvin S, Wynne B. Oral manifestations of lupus. Ir J Med Sci. 2017; 187(1):91-3
8. Albilia JB, Lam DK, Clokie CML, Sándor GKB. Systemic Lupus Erythematosus: a review for Dentists. J Can Dent Assoc. 2007; 73(9):823-8
9. Fernandes M, Taulaigo A, Vidal C, Agostini P, Riso N, Moraes-Fontes MF. Heterogeneous lupus-specific lesions and treatment outcome, in a single patient, over a period of time. Clin Case Rep. 2019; 7(5):865-71
10. Hammoudeh M, Al-Momani A, Sarakbi H, Chandra P, Hammoudeh S. Oral manifestations of Systemic Lupus Erythematosus patients in Qatar: A pilot study. Int J Rheumatol. 2018; 2018(12):1-6
11. De Rossi SS, Glick M. (1998). Lupus erythematosus: considerations for dentistry. J Am Dent Assoc. 1998; 129(3):330-9
12. Brennan MT, Valerin MA, Napeñas JJ, Lockhart PB. Oral manifestations of patients with lupus erythematosus. Dent Clin N Am. 2005; 49(1):127-41
13. Lanna CCD, Ferreira GA, Telles RW. Lúpus eritematoso sistêmico. Reumatologia: Diagnóstico e tratamento. 4th ed. São Paulo: Ed. A.C, Farmacêutica, 2014; 378-410
14. Hahn BH, Karpouzas GA, Gsao BP. Systemic lupus erythematosus and related syndromes – Pathogenesis of systemic lupus erythematosus. Kelley's Textbook of Rheumatology. USA: Elsevier Saunders ed. 2005; 1174-200
15. Rhodes B, Vyse TJ. The genetics of SLE: an update in the light of genome-wide association studies. Rheumatology. 2008; 47:1603-11
16. Muñoz LE, van Bavel C, Franz S, Berden J, Herrmann M, van der Vlag J. Apoptosis in the pathogenesis of systemic lupus erythematosus. Lupus. 2008; 17(5):371-5
17. Fu SM, Deshmukh US, Gaskin F. Pathogenesis of systemic lupus erythematosus revisited end organ resistance to damage, autoantibody initiation and diversification, and HLA-DR. J Autoimmun. 2011; 37(6):104-12
18. Akizuki S, Ishigaki K, et al. PLD4 is a genetic determinant to systemic lupus erythematosus and involved in murine autoimmune phenotypes. Ann Rheum Dis. 2019; 78(4):509-18
19. Louis PJ, Fernandes R. Review of systemic lupus erythematosus. Oral Surg Oral Med Oral Pathol Oral Radiol. 2001; 91(5):512-8
20. Bourré-Tessier J, Peschken CA, et al. Association of Smoking with cutaneous manifestations in Systemic Lupus Erythematosus. Arthritis Care Res. 2013; 65(8):1275-80
21. Kamen DL. Environmental influences on Systemic Lupus Erythematosus expression. Rheum Dis Clin North Am. 2014; 40(3):401-7
22. Mays JW, Sarmadi M, Moutsopoulos NM. Oral manifestations of systemic autoimmune and inflammatory diseases: diagnosis and clinical management. J Evid Based Dent Pract. 2012; 12(3):265-82
23. Calderaro DC, Ferreira GA, et al. Há associação entre o lúpus eritematoso sistêmico e a doença periodontal? Rev Bras Reumatol. 2016; 56(3):280-4
24. Mutlu S, Richards A, Maddison P, Scully C. Gingival and periodontal health in systemic lupus erythematosus. Community Dent Oral Epidemiol. 1993; 21(3):158-61
25. Kobayashi T, Ito S, et al. Risk of periodontitis in systemic Lupus Erythematosus is associated with Fcγ receptor polymorphisms. J Periodontol. 2003; 74(3):378-84
26. Trail AC, Claiborne DM. Treating patients with lupus. Dim Dent Hyg. 2013; 11(10):53-7
27. Gilboe IM, Kvien TK, Husby G. Disease course in systemic lupus erythematosus: changes in health status, disease activity, and organ damage after 2 years. J Rheumatol. 2001; 28:266-74
28. Grimaldo-Carjevschi M, Lòpez-Labady J, Villarroel-Dorrego M. Squamous cell carcinoma on the palate with systemic lupus erythematosus: case report and review of literature. Lupus. 2011; 20(5):519-22
29. Downey MC, Hughes CT, Winkley GP. Systemic lupus erythematosus: a review for dental professionals. J Dent Hyg. 1998; 72(2):35-40
30. Wallace DJ. Cutaneous and cutaneovascular manifestation of systemic lupus erythematosus. Dubois lupus erythematosus, 5th ed. 1997; 693-722
31. Duarte AA. Fator antinúcleo na dermatologia. Anais Bras Dermatol. 2005; 80(4):387-94
32. Vaz AJ, Takei K, Bueno EC. Imunoensaios Fundamentos e Aplicações. Guanabara Koogan. 2007
33. Sonis ST, Fazio RC, Fang L. Lesões brancas: lupo eritematoso. In: Medicina Oral. 4th ed. Rio de Janeiro, Guanabara Koogan, 1986.
34. Scully C. Medicina Oral e Maxilofacial: Bases do Diagnóstico e Tratamento. 2nd (Ed). London, Elsevier. 2008; 392
35. Chi AC, Neville BW, Krayer JW, Gonsalves WC. Oral manifestations of systemic disease. Am Family Physician. 2010; 82(11):1381-8
36. Nico MMS, Vilela MAC, Rivitti EA, Lourenço SV. Oral lesions in lupus erythematosus: correlation whit cutaneous lesions. Eur J Dermatol. 2008; 19(4):376-81
37. Callen JP. Oral manifestations of collagen vascular disease. Semin Cutan Med Surg. 1997; 116(4):323-7
38. Aliko A, Alushi A, Tafaj A, Lela F. Oral mucosa involvement in rheumatoid arthritis, systemic lupus erythematosus and systemic sclerosis. Int Dent J. 2010; 60(5):353-8
39. Shiodt M. Oral manifestations of lupus erythematosus. Int J Oral Surg. 1984; 13(2):101-47
40. Hughes CT, Downey MC, Winkley GP. Systemic lupus erythematosus: a review for dental professionals. J Dent Hyg. 1998; 72(2):35-40
41. Parslow RC, McKinney PA, Law GR, Bodansky HJ. Population mixing and childhood diabetes. Int J Epidemiol. 2001; 30(3):533-8.
42. Tsokos GC. Systemic lupus erythematosus. N Engl J Med. 2011; 365(22):2110-21
43. Mustafa MB, Porter SR, Smoller BR, Sitaru C. Oral mucosal manifestations of autoimmune skin diseases. Autoimmun Rev. 2015; 14(10):930-51
44. Orteu CH, Buchanan JA, Hutchison I, Leigh IM, Bull RH. Systemic lupus erythematosus presenting with oral mucosal lesions: easily missed? Braz J Dermatol. 2001; 144(6):1219-23
45. Delavarian Z, Chaghmaghi MA, Mozafari PM, Fard MRH, Saati S. Role of oral medicine specialist in disclosing systemic lupus erythematosus: A diagnostic dilema. Ind J Dental Edu. 2010; 3(3):121-6
46. Marques ERMC, Lourenço SV, Lima DM, Nico MMS. Oral lesions in lupus erythematosus-cytokines profiles of inflammatory infiltrate. J Cutan Pathol. 2010; 37(4):439-45
47. Lourenço SV, Carvalho FRG, et al. Lupus erythematosus: clinical and histopathological study of oral manifestations and immunohistochemical profile of the inflammatory infiltrate. J Cutan Pathol. 2007; 34(7):558-64
48. Sontheimer RD. Lupus erythematosus. Fitzapatrick’S Dermatology in General Medicine. 2003; 6(11):1677-93
49. Gonçalves LM, Bezerra Júnior JRS, da Cruz MCFN. Avaliação clínica das lesões orais associadas a doenças dermatológicas. Anais Bras Dermatol. 2010; 85(2):150-6
50. Wang Z, Wang Y, et al. Long-term survival and death causes of systemic lupus erythematosus in China: a systemic review of observational studies. Medicine. 2015; 94(17):e794
51. Kobayashi T, Ito S, et al. The combined genotypes of stimulatory and inhibitory Fcγ receptors associated with systemic lupus erythematosus and periodontitis in Japanese adults. J Periodontol. 2007; 78(3):467-74
52. Manoussakis MN, Georgopoulou C, et al. Sjorgren’s syndrome associated with systemic lupus erythematosus: clinical and laboratory profiles and comparison with primary Sjogren’s syndrome. Athritis Rheumatol. 2004; 50(3):882-91
53. Szanto A, Szodoray P, Kiss E, Kapitany A, Szegedi G, Zeher M. Clinical serologic, and genetic profiles of patients with associated Sjögrens syndrome and systemic lupus erythematosus. Human Immunol. 2006; 67(11):924-30
Authors
Cardoso, I. L. ., Leal, M. F. C. ., & Regis, R. C. D. . (2020). Systemic Lupus Erythematosus and implications for the oral cavity. Journal of Medical Care Research and Review, 3(9), 444–453. https://doi.org/10.15520/mcrr.v3i9.142
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