ANTIDIABETIC AND TOXICITY ASSESSMENT OF COMBINATION OF PIPER NIGRUM AND ARTOCARPUS HETROPYLLUS
Article Sidebar
Abstract
The worldwide prevalence of DM has risen dramatically over the past two decades, from an
estimated 30 million cases in 1985 to 285 million in 2010. Based on current trends, the
International Diabetes Federation projects that 438 million individuals will have diabetes by
the year 2030. However, on chronic usage most of these agents produced several side effects,
including hypoglycemic coma, insulin resistance, hyper-sensitivity, cholesterol, jaundice,
abdominal pain, anorexia and metallic taste [4]. For various reasons in recent years, the
popularity of herbal medicines in diabetic control has increased. Natural plant drugs are
frequently considered to be less toxic with lower side effects than synthetic ones
[7].Therefore searching herbal product with anti-diabetic activity possessing fewer side
effects receives considerable publicity and provides an opportunity to cure this disease.
Keywords: Antidiabetic, Prevalence, Hyperglycaemia, Toxicity, Diabetic Anatomy etc.
Full text article
References
V. R. Kannan, G. S. Rajasekar, P.Rajesh, V. Balasubramanian, et al.,“Anti-diabetic activity on ethanolicextracts of fruits of terminaliachebula retz. Alloxan induceddiabetic rats,” American Journal ofDrug Discovery and Development,2012.
V. Jakus and N. Rietbrock,“Advanced glycation end-productsand the progress of diabeticvascular complications,” Physiol.Res, vol. 53, pp. 131-142, 2004.
P. K. Das, S. Bhattacharya, J. N.Pandey, and M. Biswas,“Antidiabetic activity of trapanatans fruit peel exctract againststreptozotocin induced diabeticrats,” Global Journal ofPharmacology, vol. 5, no. 3, pp.186-190, 2011.
U. S. Sharma and A. Kumar,“Anti-diabetic effect of rubusellipticus fruit extract in alloxan
induced diabetic rats,” Journal of Diabetology, vol. 2, no. 4, June 2011.
American Diabetes Association.Economic costs of diabetes in theUS in 2002. Diabetes Care. 2003;26: 917-932.
M. Velraj, M. Singh, V.Ravichandiran, S. Nirmala, and S.Ragala, “Antidiabetic activity ofethyl acetate and ethanolic extractof scindapsus officinalis fruit inalloxan induced diabetic rats,” vol.3, no. 3, pp. 1305-1310, July-Sept.2011.
A. K. Datusalia, C. P. Dora, and S.Sharma, “Acute and chronichypoglycemic activity of sida tiagiifruits in N5-streptozotocin diabeticrats,” Acta PoloniaePharmaceutican Drug
Research, vol. 69, no. 4, pp. 699-706, 2012.
Marles RJ, Farnsworth N:Antidiabetic plants and their activeconstituents. Phytomedicine 1995,2(2):137–189.
Harrison's Online > Part 16.Endocrinology and Metabolism >Section 1. Endocrinology> Chapter344. Diabetes Mellitus> Epidemiology
Globalburden of diabetes. International Diabetes federation. Diabetic atlas fifth edition 201, Brussels. Yach D, Hawkes C, Gould CL, Hofman KJ (2004) The global burden of chronic diseases: overcoming impediments to prevention and control. JAMA 291: 2616 2622.
Wild S, Roglic G, Green A, SicreeR, King H (2004) Globalprevalence of diabetes: estimatesfor the year 2000 and projectionsfor 2030. Diabetes Care 27: 1047-1053
American Diabetes Association(1998) Report of the expertcommittee on the diagnosis andclassification of diabetes mellitus.Diabetes Care. 21: S5-S19.
Habtamu Wondifraw BaynestClassification, Pathophysiology,Diagnosis and Management ofDiabetes Mellitus Baynes JDiabetes Metab 2015, 6:5
Kuttan R, Joy KL, Anti-diabeticactivity of Picrorrhiza kurroa
extract, J Ethnopharmacol 1999; 167: 143-8.
Crofton, K. M. (1992). Reflexmodification and the Assessmentof Sensory Dysfunction. In:Neurotoxicology (H. A. Tilson andC. L. Mitchell, Eds.), pp. 181-212,Raven Press, New York
MEYER, J. L., AND E. T.SCHULTZ.1985. Migrating haemulid fishes as a source ofnutrients and organic matter oncoral reefs. Limnol. Oceanogr. 30:146-156.
Karunanayake EH, Hearse D J,Mellows G. The metabolic fate andelimination of streptozocin.Biochemical Society Transactions1975; 3: 410-14.7.