Anti-Diabetic potential of a Polyherbal formulation (FA1) in STZ Induced Diabetic Rats
Article Sidebar
Abstract
The aim of the present study was to determine the anti-diabetic activity of a polyherbal formulation (FA1) in streptozotocin induced diabetic rats. The ethanolic extracts of leaves of Alstonia scholaris, Heartwood of Pterocarpus marsupium, Heartwood of Embelia ribes were prepared. The wistar albino rats were injected with 60 mg/kg of streptozotocin intraperitoneally to induce diabetes. After six weeks of streptozotocin injection, polyherbal formulation (FA1) was daily administered at a dose of 200 mg/kg body weight to diabetic rats for a period of 15 days. Blood samples were collected from the retro orbital plexus of the eye and blood glucose level was estimated by glucose oxidase-peroxidase method. The study indicated that polyherbal formulation (FA1) at a dose of 200 mg/kg body weight showed significant decline in blood glucose level.
Full text article
References
2. Kirana H, Srinivasan BP. Effect of Cycleapeltata Lam roots aqueous extract on glucose levels, lipid profile, insulin, TNF α and skeletal muscle glycogen in diabetic rats. Indian J Exp Biol. 2010; 48:499–502.
3.Vats RK, Kumar V, Kothari A, Mital A, Ramachandran U. Emerging targets for diabetes. Current Science. 2005; 88(2):241–9.
4. Grover JK, Yadav S. Vats V. Medicinal plants of India with anti-diabetic potential. J Ethnopharmacol. 2002; 81:81– 100.
5. Hayat MM, Wadhan P, Singh V. Hypoglycaemic activity of flower heads of Artemisia maritime in normal and alloxan-induced diabetic rats. J Nat Remedies. 2013; 13(1):9–14.
6. Kirana H, Agrawal SS, Srinivasan BP. Aqueous extract of Ficusreligiosa Linn. reduces oxidative stress in experimentally induced diabetic rats. Indian J Exp Biol. 2007; 49:822–6.
7. Jong-Anurakkun, N., Bhandari, M. R., Kawabata, J. (2007). α-Glucosidase inhibitors from Devil tree (Alstonia scholaris). Food Chem. 103, 1319-1323.
8. Mukhtar HM, Ansari SH, Ali M, Bhatt ZA, Naved T (2005). Effect of aqueous extract of Pterocarpus marsupium wood on alloxan-induced diabetic rats. Pharmazie, 60(6):478-479.
9. Phu Hoang Dang, Nhan Trung Nguyen, Hai Xuan Nguyen, Luan Bao Nguyen, Tho Huu Le, Truong Nhat Van Do, Mao Van Can , Mai Thanh Thi Nguyen, α-Glucosidase inhibitors from the leaves of Embelia ribes. Fitoterapia, 2015 Jan;100:201-7.